Asthma: Ovalbumin sensitization and challenge

Discovery

Ovalbumin (OVA) sensitization and challenge induces allergic responses such as airway hyperresponsiveness (AHR), bronchoalveolar lavage (BAL) eosinophilia, allergic cytokines and raised systemic IgE.

Validated positive controls in this model include oral steroids dexamethasone and inhaled steroids budesonide and fluticasone propionate.

OVA sensitisation (i.p.) and aerosolised OVA challenge induces BAL eosinophilia and increases in allergic cytokines such as IL-5 (data generated in the BN rat). The induced inflammation in this model is reversed with oral treatment of the steroid Budesonide. OVA sensitisation and challenge induces AHR to methacholine, this is reversed by administration of the oral steroid Dexamethasone (data generated in the Balb/c mouse).

Study Design
Species/Strain	Dunkin-Hartley Guinea Pig, Brown Norway Rat, Balb/c mouse
Model	Ovalbumin sensitization and challenge
Relevant Use	Assessing the efficacy of novel treatments for Asthma
Readouts Available	Lung Funtion (non-invasive and invasive), AHR assessment, BAL differential cell counts, BAL cytokines, histopathology, systemic IgE

Study data generated by Labcorp Huntingdon Pharmacology.

Molecule or Product Type

Biologics, Small Molecule

Models

Guinea Pig, Mouse, Rat

Administration Routes

Dermal, Dietary, Gavage, Implant, Infusion, Inhalation, Intracranial, Intracutaneous, Intramuscular, Intranasal, Intraperitoneal, Intrathecal, Intratracheal, Intravenous, Ocular, Rectal, Subcutaneous, Transcortical, Vaginal

Regulatory

IND & CTA, NDA & BLA, Post-Market

Industry Market

Pharma

Phase

Discovery, Nonclinical

Related Models

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